The Chicago White Sox Opening Day history is based upon the first game played at home during the regular season and includes (if applicable) the entire franchise history.
How many Chicago White Sox Opening Day games were played in April? Have they ever played an Opening Day game in March? Have they even been shutout at home on Opening Day? We hope you enjoy using the charts below to review other similar Opening Day splits:
| Monthly Opening Day Splits | | Team vs Team Opening Day Splits |
| | | |
| Month (Games) | Won | Lost | WP | | Opponent (Games) | Won | Lost | WP |
| April (111) | 61 | 50 | 0.550 | | Anaheim Angels (1) | 1 | 0 | 1.000 |
| May (2) | 1 | 1 | 0.500 | | Baltimore Orioles (5) | 2 | 3 | 0.400 |
| | | Boston Red Sox (4) | 3 | 1 | 0.750 |
| Score Related Opening Day Splits | | California Angels (3) | 2 | 1 | 0.667 |
| | | Cleveland Blues (2) | 1 | 1 | 0.500 |
| Type (Games) | Won | Lost | WP | | Cleveland Indians (17) | 7 | 10 | 0.412 |
| Shutouts (21) | 13 | 8 | 0.619 | | Cleveland Naps (2) | 2 | 0 | 1.000 |
| 1-Run Games (33) | 20 | 13 | 0.606 | | Detroit Tigers (24) | 13 | 11 | 0.542 |
| Blowouts (36) | 17 | 19 | 0.472 | | Kansas City Athletics (5) | 4 | 1 | 0.800 |
| | | Kansas City Royals (6) | 5 | 1 | 0.833 |
| | | Los Angeles Angels (1) | 1 | 0 | 1.000 |
| | | Milwaukee Brewers (4) | 2 | 2 | 0.500 |
| | | Minnesota Twins (3) | 2 | 1 | 0.667 |
| | | New York Yankees (1) | 0 | 1 | 0.000 |
| | | Oakland Athletics (2) | 0 | 2 | 0.000 |
| | | Seattle Mariners (1) | 1 | 0 | 1.000 |
| | | St. Louis Browns (23) | 13 | 10 | 0.565 |
| | | Tampa Bay Rays (1) | 1 | 0 | 1.000 |
| | | Texas Rangers (4) | 2 | 2 | 0.500 |
| | | Toronto Blue Jays (1) | 0 | 1 | 0.000 |
| | | Washington Senators (3) | 0 | 3 | 0.000 |
During their Opening Day history, the Chicago White Soxscored the most runs (15) on April 14, 1908 versus the . The most runs scored against them during an Opening Day game was 16 and it was played on April 18, 1991 versus the .
