The San Diego Padres Opening Day history is based upon the first game played at home during the regular season and includes (if applicable) the entire franchise history.
How many San Diego Padres Opening Day games were played in April? Have they ever played an Opening Day game in March? Have they even been shutout at home on Opening Day? We hope you enjoy using the charts below to review other similar Opening Day splits:
| Monthly Opening Day Splits | | Team vs Team Opening Day Splits |
| | | |
| Month (Games) | Won | Lost | WP | | Opponent (Games) | Won | Lost | WP |
| March (2) | 1 | 1 | 0.500 | | Arizona Diamondbacks (2) | 1 | 1 | 0.500 |
| April (43) | 22 | 21 | 0.512 | | Atlanta Braves (6) | 4 | 2 | 0.667 |
| | | Cincinnati Reds (4) | 2 | 2 | 0.500 |
| Score Related Opening Day Splits | | Colorado Rockies (2) | 0 | 2 | 0.000 |
| | | Florida Marlins (1) | 1 | 0 | 1.000 |
| Type (Games) | Won | Lost | WP | | Houston Astros (4) | 2 | 2 | 0.500 |
| Shutouts (7) | 3 | 4 | 0.429 | | Los Angeles Dodgers (7) | 3 | 4 | 0.429 |
| 1-Run Games (12) | 7 | 5 | 0.583 | | New York Mets (1) | 1 | 0 | 1.000 |
| Blowouts (14) | 9 | 5 | 0.643 | | Pittsburgh Pirates (3) | 2 | 1 | 0.667 |
| | | San Francisco Giants (15) | 7 | 8 | 0.467 |
During their Opening Day history, the San Diego Padresscored the most runs (17) on April 12, 2010 versus the . The most runs scored against them during an Opening Day game was 13 and it was played on April 13, 1987 versus the .
