The St. Louis Cardinals Opening Day history is based upon the first game played at home during the regular season and includes (if applicable) the entire franchise history.
How many St. Louis Cardinals Opening Day games were played in April? Have they ever played an Opening Day game in March? Have they even been shutout at home on Opening Day? We hope you enjoy using the charts below to review other similar Opening Day splits:
| Monthly Opening Day Splits | | Team vs Team Opening Day Splits |
| | | |
| Month (Games) | Won | Lost | WP | | Opponent (Games) | Won | Lost | WP |
| March (3) | 2 | 1 | 0.667 | | Atlanta Braves (1) | 1 | 0 | 1.000 |
| April (125) | 66 | 59 | 0.528 | | Chicago Colts (2) | 0 | 2 | 0.000 |
| May (4) | 3 | 1 | 0.750 | | Chicago Cubs (31) | 16 | 15 | 0.516 |
| | | Chicago Orphans (2) | 0 | 2 | 0.000 |
| Score Related Opening Day Splits | | Cincinnati Porkers (1) | 1 | 0 | 1.000 |
| | | Cincinnati Red Stockings (3) | 2 | 1 | 0.667 |
| Type (Games) | Won | Lost | WP | | Cincinnati Reds (12) | 7 | 5 | 0.583 |
| Shutouts (17) | 13 | 4 | 0.765 | | Cleveland Spiders (2) | 2 | 0 | 1.000 |
| 1-Run Games (38) | 20 | 18 | 0.526 | | Colorado Rockies (3) | 2 | 1 | 0.667 |
| Blowouts (37) | 24 | 13 | 0.649 | | Houston Astros (1) | 1 | 0 | 1.000 |
| | | Indianapolis Blues (1) | 1 | 0 | 1.000 |
| | | Los Angeles Dodgers (3) | 2 | 1 | 0.667 |
| | | Louisville Colonels (2) | 2 | 0 | 1.000 |
| | | Louisville Eclipse (1) | 1 | 0 | 1.000 |
| | | Milwaukee Braves (2) | 1 | 1 | 0.500 |
| | | Milwaukee Brewers (4) | 2 | 2 | 0.500 |
| | | Montreal Expos (7) | 3 | 4 | 0.429 |
| | | New York Mets (6) | 2 | 4 | 0.333 |
| | | Philadelphia Phillies (7) | 5 | 2 | 0.714 |
| | | Pittsburgh Alleghenys (2) | 1 | 1 | 0.500 |
| | | Pittsburgh Pirates (33) | 17 | 16 | 0.515 |
| | | San Diego Padres (1) | 0 | 1 | 0.000 |
| | | San Francisco Giants (4) | 1 | 3 | 0.250 |
| | | Toledo Maumees (1) | 1 | 0 | 1.000 |
During their Opening Day history, the St. Louis Cardinalsscored the most runs (14) on April 11, 1928 versus the . The most runs scored against them during an Opening Day game was 14 and it was played on April 12, 1892 versus the .
