When Ken Williams took over as General Manager of the Chicago White Sox in 2000 he, along with White Sox Manager Jerry Manuel became the first all-minority manager / general manager combo in Major League history.
Did you know that the youngest General Manager in history to date is Theo Epstein of the Boston Red Sox? Upon taking the position at age twenty-eight he said, "The best advice I got was given by Buzzie Bavasi. He said to remember that every time you're about to make a deal, the guy on the other end of the phone is just as smart as you are, probably smarter."
The first use of the General Manager label during baseball was applied to former American League umpire William "Billy" Evans in 1927 who was the General Manager of the Cleveland Indians.