2008 Strikeouts Leaders Top 25 in the American League
Name	Strikeouts	Team	Rank
A.J. Burnett	231	Toronto Blue Jays	1
Ervin Santana	214	Los Angeles Angels of Anaheim	2
Roy Halladay	206	Toronto Blue Jays	3
Javier Vazquez	200	Chicago White Sox	4
Zack Greinke	183	Kansas City Royals	5
Gil Meche	183	Kansas City Royals
Felix Hernandez	175	Seattle Mariners	7
Josh Beckett	172	Boston Red Sox	8
Cliff Lee	170	Cleveland Indians	9
Scott Kazmir	166	Tampa Bay Rays	10
Justin Verlander	163	Detroit Tigers	11
James Shields	160	Tampa Bay Rays	12
Andy Pettitte	158	New York Yankees	13
John Danks	155	Chicago White Sox	14
Daisuke Matsuzaka	154	Boston Red Sox	15
Jon Lester	152	Boston Red Sox	16
Jered Weaver	152	Los Angeles Angels of Anaheim
Mike Mussina	150	New York Yankees	18
Gavin Floyd	145	Chicago White Sox	19
Scott Baker	141	Minnesota Twins	20
Mark Buehrle	140	Chicago White Sox	21
John Lackey	130	Los Angeles Angels of Anaheim	22
Matt Garza	128	Tampa Bay Rays	23
Vicente Padilla	127	Texas Rangers	24
Armando Galarraga	126	Detroit Tigers	25
Name	Strikeouts	Team	Rank

	Jose Cruz of the Houston Astros had his number twenty-five retired on October 3, 1992, and became the first Major League player with that particular retired number. Jim Thome wore number twenty-five since he first came up with the Cleveland Indians making him the franchise record holder for that particular number (Mike Garcia is second). The first player from the Angels franchise (they were the California Angels at the time) to wear the number twenty-five was Bob Perry.