The Cleveland Indians Opening Day history is based upon the first game played at home during the regular season and includes (if applicable) the entire franchise history.
How many Cleveland Indians Opening Day games were played in April? Have they ever played an Opening Day game in March? Have they even been shutout at home on Opening Day? We hope you enjoy using the charts below to review other similar Opening Day splits:
| Monthly Opening Day Splits | | Team vs Team Opening Day Splits |
| | | |
| Month (Games) | Won | Lost | WP | | Opponent (Games) | Won | Lost | WP |
| March (1) | 1 | 0 | 1.000 | | Anaheim Angels (2) | 2 | 0 | 1.000 |
| April (109) | 56 | 53 | 0.514 | | Baltimore Orioles (5) | 3 | 2 | 0.600 |
| May (3) | 1 | 2 | 0.333 | | Boston Red Sox (6) | 3 | 3 | 0.500 |
| | | California Angels (1) | 0 | 1 | 0.000 |
| Score Related Opening Day Splits | | Chicago White Sox (20) | 9 | 11 | 0.450 |
| | | Chicago White Stockings (1) | 0 | 1 | 0.000 |
| Type (Games) | Won | Lost | WP | | Detroit Tigers (32) | 18 | 14 | 0.563 |
| Shutouts (17) | 9 | 8 | 0.529 | | Kansas City Athletics (2) | 1 | 1 | 0.500 |
| 1-Run Games (35) | 20 | 15 | 0.571 | | Kansas City Royals (2) | 2 | 0 | 1.000 |
| Blowouts (28) | 12 | 16 | 0.429 | | Los Angeles Angels (1) | 1 | 0 | 1.000 |
| | | Los Angeles Angels of Anaheim (1) | 1 | 0 | 1.000 |
| | | Milwaukee Brewers (5) | 2 | 3 | 0.400 |
| | | Minnesota Twins (5) | 4 | 1 | 0.800 |
| | | New York Yankees (6) | 2 | 4 | 0.333 |
| | | Seattle Mariners (1) | 1 | 0 | 1.000 |
| | | St. Louis Browns (15) | 8 | 7 | 0.533 |
| | | Texas Rangers (4) | 0 | 4 | 0.000 |
| | | Toronto Blue Jays (3) | 1 | 2 | 0.333 |
| | | Washington Senators (1) | 0 | 1 | 0.000 |
During their Opening Day history, the Cleveland Indiansscored the most runs (15) on April 11, 1997 versus the . The most runs scored against them during an Opening Day game was 15 and it was played on April 1, 2011 versus the .
